Drug intelligence / Profile preview

hepalatide + peginterferon alfa-2a + tenofovir alafenamide

Development stage
Preclinical
Lead developer
Shanghai Hepu Pharmaceutical
Modality
Recombinant Proteins and Enzymes, Peptides, Small Molecules
Administration
Oral, Subcutaneous
01

Overview

This drug is a combination therapy comprised of **hepalatide**, **peginterferon alfa-2a**, and **tenofovir alafenamide**. Peginterferon alfa-2a is a recombinant interferon that stimulates the innate antiviral immune response by binding to type 1 interferon receptors, activating the JAK/STAT pathway and upregulating antiviral genes. Tenofovir alafenamide is a prodrug of tenofovir, a small molecule nucleotide reverse transcriptase inhibitor that disrupts viral DNA synthesis by competing with deoxyadenosine 5’-triphosphate, leading to DNA chain termination and ultimately inhibiting hepatitis B virus (HBV) and HIV replication. Hepalatide is not a standard approved drug and does not have a well-established profile in leading databases; it may be an experimental peptide or proprietary compound with presumed antiviral or immunomodulatory properties. The rationale for combining these agents is likely to leverage multiple mechanisms against chronic hepatitis B or other viral liver diseases, using immune stimulation, direct viral inhibition, and potentially peptide-based modulation.

02

Targets

IFNAR2 (Interferon alpha/beta receptor subunit 2)IFNAR1 (Interferon alpha/beta receptor 1)HBV Pol (Hepatitis B virus polymerase)

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