heparan sulfate 18-mer

Heparan sulfate 18-mer is a synthetic, structurally homogeneous octadecasaccharide designed as a multi-target anti-inflammatory therapeutic agent. It is composed of a repeating IdoA2S-GlcNS disaccharide structure and is produced using a specialized chemoenzymatic synthesis method. Unlike naturally occurring heparin, this 18-mer is engineered to be non-anticoagulant and resistant to degradation by heparanase. Its mechanism of action involves the neutralization of pro-inflammatory mediators, specifically extracellular histone H3 and high mobility group box 1 (HMGB1), while also modulating apolipoprotein A-I (ApoA-I) to facilitate the dissociation of toxic HMGB1-LPS complexes. The compound is primarily being investigated for its potential to improve survival and reduce tissue injury in conditions characterized by overwhelming inflammation, such as sepsis and acetaminophen-induced acute liver failure.

Other names

heparan sulfate octadecasaccharidesynthetic heparan sulfate 18-mer18-mer heparan sulfate