heparin disaccharide iii-s

Heparin disaccharide III-S is a synthetic or semi-synthetic disaccharide derived from the enzymatic digestion of heparan sulfate and heparin. It is a complex carbohydrate with notable anticoagulant and anti-inflammatory properties. This compound is used primarily in research to study protein-protein interactions and enzymatic activity related to glycosaminoglycans. Structurally, it contains two carbohydrate moieties linked together with multiple sulfate groups. Its mechanism of action involves mimicking specific sulfated motifs found in natural heparins that interact with proteins such as antithrombin III and platelet factor 4 (PF4), which are central to coagulation pathways[1][2][4][7]. Heparin disaccharide III-S itself is not approved for clinical use but serves as an important tool for dissecting structure-function relationships in anticoagulant drug development.

Other names

HEPARIN DISACCHARIDE III-S(2r,3r,4s)-2-(((2r,3s,4r,5r,6s)-4,6-dihydroxy-2-(hydroxymethyl)-5-(sulfonatoamino)oxan-3-yl)oxy)-4-hydroxy-3-(sulfonatooxy)-3,4-dihydro-2h-pyran-6-carboxylateCHEBI:42917