Drug intelligence / Profile preview

hepatitis A vaccine (GSK)

Development stage
Approved
Lead developer
GSK
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

Hepatitis A vaccines are biologics used to provide active immunity against the hepatitis A virus (HAV). Most commercially available formulations are inactivated virus vaccines, although live-attenuated versions are used in certain regions. The vaccine is typically produced by growing the virus in human cell culture (such as MRC-5 cells), followed by purification and inactivation with formaldehyde. It is often adsorbed onto an aluminum-based adjuvant to enhance immunogenicity. The vaccine works by inducing the production of neutralizing antibodies against HAV, providing long-term protection against hepatitis A infection. It is recommended for routine pediatric immunization, travelers to endemic areas, and individuals at increased risk of infection.

Brand names
HavrixVaqtaAvaximEpaxalHealive
Other names
Hepatitis A virus vaccineHepA vaccineHepatitis-A vaccine
02

Targets

Hepatitis A virus capsid protein

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