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Drug intelligence / Profile preview
hepatitis B monovalent vaccine
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
The hepatitis B monovalent vaccine is a preventive biologic product designed to induce immunity against the hepatitis B virus (HBV). It contains purified recombinant hepatitis B surface antigen (HBsAg), produced in yeast cells or other expression systems, and formulated with an adjuvant such as aluminum salts or, in the case of Heplisav-B, a synthetic immunostimulatory oligonucleotide. The mechanism of action involves stimulating the immune system to produce protective antibodies against HBsAg, thereby preventing infection by HBV. The primary indication is prevention of hepatitis B infection and its complications—including chronic liver disease and hepatocellular carcinoma—in all age groups from birth onward[3][6][10]. Multiple formulations are available for different age groups and risk populations.
- Brand names
- Engerix-BRecombivax HBHeplisav-B
- Other names
- hepatitis B vaccine recombinantHepB vaccineHBV vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)TLR9 (Toll-like receptor 9)
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