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hepatitis B vaccine (Massachusetts General Hospital)
- Development stage
- Unknown
- Lead developer
- Merck
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
A recombinant protein subunit vaccine consisting of the hepatitis B surface antigen (HBsAg), used for active immunization to prevent infection caused by all known subtypes of the hepatitis B virus (HBV). In the context of a clinical trial (NCT02057263) conducted by Massachusetts General Hospital, this standard vaccine was evaluated in healthy adults aged 40-70 to determine if the bisphosphonate medication alendronate could serve as an adjuvant to enhance the humoral immune response. The vaccine works by stimulating the immune system to produce neutralizing antibodies (anti-HBs) against the viral surface antigen, providing long-term protection against the pathogen.
- Brand names
- Sci-B-VacEngerix-B
- Other names
- Hepatitis B Vaccine (Recombinant)HBsAg vaccineRecombinant Hepatitis B Surface Antigen Vaccine
02
Targets
HBsAg (Hepatitis B surface antigen)
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