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Drug intelligence / Profile preview
hepatitis B vaccine (recombinant), adjuvanted
- Development stage
- Approved
- Lead developer
- Dynavax Technologies
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
Heplisav-B (Hepatitis B Vaccine [Recombinant], Adjuvanted) is a biologic vaccine developed by Dynavax Technologies for the prevention of infection caused by all known subtypes of the Hepatitis B virus in adults aged 18 and older. Approved by the FDA in 2018, it is a recombinant protein subunit vaccine that combines Hepatitis B surface antigen (HBsAg) with a proprietary synthetic cytosine phosphoguanine oligonucleotide adjuvant, CpG 1018. The CpG 1018 adjuvant acts as a Toll-like receptor 9 (TLR9) agonist, stimulating the innate immune system to enhance the adaptive immune response to the HBsAg. This adjuvanted formulation allows for a two-dose immunization series completed within one month, providing a more efficient alternative to traditional three-dose Hepatitis B vaccines.
- Brand names
- Heplisav-B
- Other names
- Hepatitis B Vaccine [Recombinant], Adjuvanted
02
Targets
HBsAg (Hepatitis B surface antigen)TLR9 (Toll-like receptor 9)
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