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This entry refers to a grouping of four distinct vaccine types—hepatitis B vaccine, rabies vaccine, human papillomavirus (HPV) vaccine, and influenza vaccine—that are being evaluated together in a retrospective cohort study (NCT06180447) in China. Led by investigator Sun Xin at West China Hospital, the study utilizes data from the REPRESENT pregnancy registry to assess the risk of adverse pregnancy outcomes, such as birth defects, preterm birth, and low birth weight, following maternal exposure to these vaccines during the peri-conceptional period or pregnancy. Each vaccine in this group is a biologic composed of pathogen-specific antigens (such as viral proteins or inactivated components) designed to prevent their respective infectious diseases. While each vaccine type is individually approved and manufactured by various companies, this specific combination is the focus of safety surveillance regarding maternal and fetal health.
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