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Hepatitis B virus vaccine refers to the recombinant subunit vaccines used to prevent infection by the hepatitis B virus (HBV). These vaccines typically contain the hepatitis B surface antigen (HBsAg), produced using recombinant DNA technology in yeast or mammalian cells. In the context of clinical research at Assiut University, this vaccine is being evaluated in patients with inflammatory bowel disease (IBD), such as Crohn's disease and ulcerative colitis. These patients often exhibit a diminished immune response to standard vaccination schedules due to their underlying condition and the use of immunosuppressive therapies. The research specifically compares the efficacy of an accelerated dosing regimen (administered at 0, 1, and 3 months) against the standard regimen (administered at 0, 2, and 6 months) to determine if a faster schedule can achieve protective antibody levels more effectively in this immunocompromised population.
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