Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
hepatocyte growth factor-modified mesenchymal stem cells
- Development stage
- Unknown
- Lead developer
- Institute of Radiation Medicine, Academy of Military Medical Sciences
- Modality
- Cell Therapies, Gene Therapies
- Administration
- Intravenous
01
Overview
Hepatocyte growth factor-modified mesenchymal stem cells (HGF-MSCs) are an experimental, preclinical and early clinical-stage gene-modified cell therapy. Mesenchymal stem cells (MSCs), derived from sources such as bone marrow or umbilical cord, are genetically engineered (often via lentiviral or adenoviral vectors) to overexpress hepatocyte growth factor (HGF). HGF is a pleiotropic cytokine and growth factor that promotes cell survival, tissue regeneration, and angiogenesis while suppressing inflammation and fibrosis. The genetic modification is designed to enhance the survival, homing, and therapeutic efficacy of the transplanted MSCs in hostile microenvironments. HGF-MSCs have been investigated in preclinical models of acute lung injury, myocardial infarction, liver fibrosis, spinal cord injury, and rheumatoid arthritis-associated interstitial lung disease (RA-ILD). A small clinical study has also evaluated autologous HGF-modified bone marrow MSCs for the treatment of pulmonary silicosis.
- Other names
- HGF gene-modified MSCsHGF-BM-MSCsHGF-MSCsHGF-overexpressing mesenchymal stem cellsHGF-UCMSCsHGF/MSCsMSCs/HGF
Beyond the preview
Go deeper on hepatocyte growth factor-modified mesenchymal stem cells.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on hepatocyte growth factor-modified mesenchymal stem cells.