Hepatocyte Transplantation

Hepatocyte Transplantation (Virginia Commonwealth University) is an investigational cell-based therapy involving the infusion of isolated human hepatocytes into the liver or spleen. Developed by researchers at Virginia Commonwealth University, this therapy utilizes fresh or cryopreserved hepatocytes, typically sourced from donor livers unsuitable for whole-organ transplantation, to restore or supplement liver function. The procedure is primarily evaluated as a bridge to orthotopic liver transplantation or as a potential bridge to recovery in patients with acute liver failure and chronic liver disease. Additionally, it is studied for the treatment of inherited metabolic disorders, including Crigler-Najjar syndrome, familial hypercholesterolemia, and urea cycle disorders, by providing the functional enzymes or receptors (such as UGT1A1 or LDLR) missing in the recipient's native liver cells.

Other names

Human Hepatocyte TransplantationHepatocyte Transplantation for Liver FailureHepatocyte Transplantation-Virginia Commonwealth University-acute liver failure-chronic liver disease-Crigler-Najjar syndrome-familial hypercholesterolemia-urea cycle disorders