Drug intelligence / Profile preview

heptavalent botulinum vaccine

Development stage
Preclinical
Lead developer
United States Army
Modality
DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration
Subcutaneous
01

Overview

**Heptavalent botulinum vaccine** refers to an investigational multivalent vaccine concept designed to induce protective neutralizing antibodies against all seven classical botulinum neurotoxin serotypes A through G. In the literature and patent record, such vaccines have generally been described as recombinant protein or DNA-based immunogens built from non-toxic fragments of botulinum neurotoxin, especially heavy-chain receptor-binding domains, with the goal of preventing botulism caused by *Clostridium botulinum* neurotoxins. Unlike the licensed heptavalent botulism antitoxin BAT, this is a prophylactic vaccine concept rather than a post-exposure antitoxin product. Publicly available sources support the existence of botulinum neurotoxin vaccine platforms and mono- or multivalent vaccine approaches, but do not clearly identify a single marketed product, unique brand name, or consistently named clinical-stage asset specifically called heptavalent botulinum vaccine.

Other names
heptavalent botulinum vaccinebotulinum neurotoxin vaccinemultivalent botulinum vaccine
02

Targets

BoNT/G (Botulinum neurotoxin type G)BoNT/F (Botulinum neurotoxin type F)BoNT/E (Botulinum neurotoxin type E)BoNT/A (Botulinum neurotoxin type A)BoNT/B (Botulinum neurotoxin type B)BoNT/C (Botulinum neurotoxin type C)BoNT/D (Botulinum neurotoxin type D)

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