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HER2×AXL bispecific ADC
- Development stage
- Preclinical
- Lead developer
- AbTis
- Modality
- Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Cytotoxic ADCs → Antibody-Drug Conjugates (ADCs) → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
HER2×AXL bispecific ADC is a bispecific antibody-drug conjugate (ADC) designed to simultaneously target Human Epidermal Growth Factor Receptor 2 (HER2) and AXL receptor tyrosine kinase. Developed by AbTis and Dong-A ST using the eKiH (enhanced knob-into-hole) platform, this agent aims to overcome tumor heterogeneity and resistance mechanisms, such as epithelial-mesenchymal transition (EMT), which are often driven by AXL signaling. The ADC can be conjugated with various payloads, including monomethyl auristatin E (MMAE) or exatecan (a topoisomerase-I inhibitor), and has shown preclinical efficacy in HER2-expressing solid tumors like lung, breast, and gastric cancers, particularly those refractory to standard therapies.
- Other names
- HER2xAXL BsAbHER-2xAXL BsAbHER 2xAXL BsAb
02
Targets
ERBB2 (Erb-b2 receptor tyrosine kinase 2)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)FCGRT (Neonatal crystallizable fragment receptor)AXL (AXL receptor tyrosine kinase)
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