HER2-affibody NIR conjugate

HER2-affibody NIR conjugate is a near-infrared (NIR) fluorescently labeled affibody conjugate developed for the non-invasive in vivo optical imaging of HER2-expressing tumors. The conjugate consists of a small (~7 kDa) HER2-specific affibody molecule (derived from the Z domain of Staphylococcus aureus protein A) site-specifically conjugated at its C-terminal cysteine residue to a near-infrared fluorescent dye (such as DyLight-750, DyLight-488, or Alexa Fluor 750). It binds with high affinity to the extracellular domain of HER2 without interfering with the binding of therapeutic antibodies like trastuzumab or pertuzumab. This imaging agent is designed to assess HER2 receptor status in breast cancer and other HER2-positive malignancies, potentially facilitating patient selection and monitoring of HER2 expression during therapy.

Other names

Affibody-Alexa Fluor 750 conjugateAffibody-DyLight-488 conjugateAffibody-DyLight488 conjugateAffibody-DyLight 488 conjugateAffibody-DyLight-750 conjugateAffibody-DyLight750 conjugateAffibody-DyLight 750 conjugateHER2-Affibody-DyLight-488 conjugateHER-2-Affibody-DyLight-488 conjugateHER 2-Affibody-DyLight-488 conjugateHER2-Affibody-DyLight-750 conjugateHER-2-Affibody-DyLight-750 conjugateHER 2-Affibody-DyLight-750 conjugateZHER2-Alexa Fluor 750 conjugateZHER-2-Alexa Fluor 750 conjugateZHER 2-Alexa Fluor 750 conjugateZHER2-DyLight-488ZHER-2-DyLight-488ZHER 2-DyLight-488ZHER2-DyLight-488 conjugateZHER-2-DyLight-488 conjugateZHER 2-DyLight-488 conjugateZHER2-DyLight-750ZHER-2-DyLight-750ZHER 2-DyLight-750ZHER2-DyLight-750 conjugateZHER-2-DyLight-750 conjugateZHER 2-DyLight-750 conjugateZHER2-GS-Cys-Alexa Fluor 750ZHER-2-GS-Cys-Alexa Fluor 750ZHER 2-GS-Cys-Alexa Fluor 750ZHER2-GS-Cys-DyLight-488ZHER-2-GS-Cys-DyLight-488ZHER 2-GS-Cys-DyLight-488ZHER2-GS-Cys-DyLight-750ZHER-2-GS-Cys-DyLight-750ZHER 2-GS-Cys-DyLight-750