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HER2-IGFBP2-IGF1R vaccine
- Development stage
- Unknown
- Lead developer
- Aston Sci
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
HER2-IGFBP2-IGF1R vaccine (WOKVAC) is a multi-antigen, polyepitope plasmid DNA-based therapeutic cancer vaccine developed by the Cancer Vaccine Institute at the University of Washington, in collaboration with EpiThany and Aston Sci. The vaccine consists of the mammalian expression vector pUMVC3 encoding Th1-selective epitopes of three tumor-associated antigens overexpressed in breast cancer: human epidermal growth factor receptor 2 (HER2), insulin-like growth factor-binding protein 2 (IGFBP-2), and insulin-like growth factor 1 receptor (IGF-1R). Administered intradermally in combination with sargramostim (GM-CSF) as an adjuvant, the vaccine transfects local cells to express these epitopes, stimulating a robust and durable type 1 helper T-cell (Th1) immune response against tumor cells expressing these antigens. WOKVAC is being evaluated in Phase I and Phase II clinical trials for the treatment and prevention of recurrence in various breast cancer subtypes, including HER2-positive breast cancer and ductal carcinoma in situ (DCIS).
- Brand names
- WOKVAC
- Other names
- pUMVC3-IGFBP2-HER2-IGF1R Plasmid DNA VaccinepUMVC-3-IGFBP2-HER2-IGF1R Plasmid DNA VaccinepUMVC 3-IGFBP2-HER2-IGF1R Plasmid DNA VaccinepUMVC3-IGFBP2-HER2-IGF1R vaccinepUMVC-3-IGFBP2-HER2-IGF1R vaccinepUMVC 3-IGFBP2-HER2-IGF1R vaccineWOKVAC vaccine
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)IGFBP2 (Insulin-like growth factor binding protein II)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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