HER2-PAT

HER2-PAT is a bispecific T-cell engager (TCE) consisting of two tandem single-chain variable fragments (scFvs) that target human epidermal growth factor receptor 2 (HER2) and CD3. It represents the unmasked, active core of the prodrug HER2-XPAT (also known as AMX-818, SAR446309, or VIR-5818). While HER2-PAT exhibits potent in vitro T-cell-mediated cytotoxicity against HER2-expressing tumor cells, its systemic administration in vivo is associated with severe on-target, off-tumor toxicities and cytokine release syndrome (CRS). Consequently, it is primarily utilized in preclinical research as a comparator to evaluate the therapeutic index and safety margins of its masked prodrug counterpart, HER2-XPAT.

Other names

cleaved HER2-XPATcleaved XPATunmasked HER2-PATunmasked HER2-XPATuTCE