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Hericium erinaceus polysaccharides
- Development stage
- Preclinical
- Lead developer
- Quzhou People's Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Hericium erinaceus polysaccharides (HEPs) are bioactive macromolecules extracted from the fruiting bodies or mycelia of the edible and medicinal mushroom Hericium erinaceus (commonly known as Lion's Mane). HEPs exhibit a wide range of pharmacological activities, including immunomodulatory, anti-inflammatory, antioxidant, neuroprotective, and gastroprotective effects. In preclinical models, HEPs have been shown to delay lung aging and the progression of chronic obstructive pulmonary disease (COPD) via the gut-lung axis. This mechanism involves reshaping the gut microbiota to promote the enrichment of the microbial metabolite 3-hydroxybutyric acid (3-HA), which subsequently activates the AMP-activated protein kinase (AMPK) signaling pathway, enhances autophagy, and improves mitochondrial function. HEPs are also investigated for their potential in treating gastrointestinal disorders, type 2 diabetes, and cognitive decline.
- Other names
- HEPsHericium erinaceus polysaccharideLion's Mane mushroom polysaccharides
02
Targets
AMPK (Adenosine monophosphate–activated protein kinase)MAPK3 (Mitogen-activated protein kinase 1)MYD88 (Myeloid differentiation primary response protein MyD88)NF-κBSREBP-1 / SREBF1 (SREBP-1)TLR4 (Toll-like receptor 4)CLEC7A (Dectin-1)
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