HET0016

HET0016 (N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidine) is a potent and selective small molecule inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis. It primarily acts by inhibiting enzymes in the cytochrome P450 4A (CYP4A) and 4F (CYP4F) families, which are responsible for the omega-oxidation of arachidonic acid to 20-HETE. 20-HETE is a bioactive lipid that plays a significant role in promoting tumor cell proliferation, migration, and neovascularization. In preclinical studies, HET0016 has been shown to reduce tumor aggressiveness, inhibit angiogenesis, and disrupt vascular mimicry in models of glioblastoma and triple-negative breast cancer. It also appears to modulate the IL-8/CXCR2 signaling pathway, further contributing to its anti-tumor effects.

Other names

N-hydroxy-N'-(4-butyl-2-methylphenyl)formamidineN-hydroxy-N'-(4-butyl-2-methylphenyl)methanimidamide