heterologous type I collagen

**Heterologous type I collagen** is a purified collagen product derived from non-human animal sources, commonly equine (horse) tendon, and used for biomedical, pharmaceutical, and cosmetic applications, primarily as a regenerative biomaterial and injectable medical device[1][3][4]. It acts as a substrate for cell adhesion, growth, and differentiation of connective tissue cells, promoting fibroblast proliferation, extracellular matrix (ECM) reconstruction, and facilitating physiological neoformation of human collagen. Its main clinical applications include the management of skin aging (biorevitalization), treatment of connective tissue injuries, and as an adjunct in therapies for disorders such as vitiligo, where it may enhance repigmentation by stimulating melanogenesis and ECM repair[3][4]. Products such as Linerase use sterile, pyrogen-free equine-derived type I collagen for intradermal injections, typically administered by healthcare professionals in protocols that include repeated sessions[3]. Mechanistically, it supports tissue regeneration, modulates local inflammatory response, and provides a scaffold for new ECM synthesis[1][4].

Brand names

Linerase

Other names

HTIC