Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
Hex-hR1
- Development stage
- Preclinical
- Lead developer
- Gilead Sciences
- Modality
- Antibody Fragments → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Hex-hR1 is a hexavalent, multivalent antibody construct targeting the insulin-like growth factor 1 receptor (IGF-IR). Developed using the proprietary Dock-and-Lock (DNL) platform technology by Immunomedics and IBC Pharmaceuticals, Hex-hR1 consists of six Fab fragments of the humanized anti-IGF-IR antibody hR1 tethered to a common Fc region. This high-valency design allows for more potent down-regulation of IGF-IR compared to the parental bivalent hR1 IgG. Preclinical studies in renal cell carcinoma (RCC) models have demonstrated that Hex-hR1 inhibits colony formation and acts synergistically with mTOR inhibitors such as temsirolimus to suppress tumor cell growth.
02
Targets
FCGRT (Neonatal crystallizable fragment receptor)Insulin receptor/Insulin-like growth factor 1 receptor hybrid receptorIGF-1R (Insulin-like growth factor 1 receptor)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)
Beyond the preview
Go deeper on Hex-hR1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Hex-hR1.