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Drug intelligence / Profile preview
HeZhong JianPi Decoction
- Development stage
- Unknown
- Lead developer
- Shanghai Municipal Hospital of Traditional Chinese Medicine
- Administration
- Oral
01
Overview
HeZhong JianPi Decoction is a Traditional Chinese Medicine (TCM) herbal formula developed by the Shanghai Municipal Hospital of Traditional Chinese Medicine for the treatment of gastroesophageal reflux disease (GERD). The formula is specifically investigated for its potential to assist in the withdrawal of proton pump inhibitors (PPIs) in patients with PPI-dependent GERD. Its therapeutic rationale is based on the TCM principles of "HeZhong" (harmonizing the middle burner/stomach) and "JianPi" (strengthening the spleen) to address gastrointestinal dysfunction. Clinical trials conducted in Shanghai have evaluated the decoction's efficacy both as a standalone therapy and in combination with Western medications like rabeprazole and omeprazole to facilitate drug withdrawal and prevent symptom recurrence.
- Brand names
- Hezhong-jianpi decoction
- Other names
- Hezhong-Jianpi decoction和中健脾方
02
Targets
NTRK2 (Tropomyosin-related kinase receptor type B)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NF-κB
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