Hi1a

Hi1a is a disulfide-rich, 76-amino-acid double-knot peptide originally isolated from the venom of the K'gari (Fraser Island) funnel-web spider (*Hadronyche infensa*). It acts as a highly potent and selective inhibitor of acid-sensing ion channel 1a (ASIC1a). During ischemic events such as stroke or myocardial infarction, tissue acidosis activates ASIC1a, leading to toxic calcium overload and cell death. By blocking ASIC1a, Hi1a prevents this cell death pathway, offering significant neuroprotective and cardioprotective benefits. Hi1a is being developed by Infensa Bioscience (as a clinical-stage miniaturized peptide analog, IB409) and the University of Queensland for the treatment of myocardial infarction, stroke, and for the preservation of donor hearts during transplantation. It is also being investigated preclinically for multiple sclerosis, spinal cord injury, and renal ischemia-reperfusion injury.

Other names

Double-knot toxinSF1 peptideSF-1 peptideSF 1 peptidepi-HXTX-Hi1api-HXTX-Hi-1api-HXTX-Hi 1api-hexatoxin-Hi1api-hexatoxin-Hi-1api-hexatoxin-Hi 1aπ-HXTX-Hi1aπ-hexatoxin-Hi1a