Drug intelligence / Profile preview

hibiscus asper extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral, Intraperitoneal
01

Overview

**Hibiscus asper extract** refers to extracts prepared from the leaves (and sometimes calyx) of the *Hibiscus asper* plant, most often using methanol or water as solvents. The extract contains bioactive compounds, including flavonoids, phenolics, saponins, terpenoids, alkaloids, tannins, glycosides, and essential fatty acids such as linoleic acid and methyl esters. Preclinical studies have shown the methanolic and aqueous extracts possess significant anti-inflammatory, antioxidant, antimicrobial, neuroprotective, anxiolytic, antidepressant, and antimalarial activities. Mechanisms of action involve inhibition of prostaglandin synthesis and histamine-mediated inflammation, antioxidant free radical scavenging, and—according to molecular docking studies—potential direct inhibition of malarial parasite enzymes. Extracts are traditionally used for inflammatory conditions (including rheumatoid arthritis), neurological disorders such as Parkinson's disease, and as part of malaria management as well as broad ethnomedicinal uses for jaundice, joint pain, anemia, abscesses, urethritis, skin infections, and male infertility.

Brand names
hibiscus asper extract
Other names
Hibiscus asper leaf extractHibiscus asper methanolic extractHibiscus asper aqueous extractHibiscus asper oil
02

Targets

Pf6PGD (Plasmodium falciparum 6-phosphogluconate dehydrogenase)PfPNP (Plasmodium falciparum purine nucleoside phosphorylase)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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