Drug intelligence / Profile preview

hibiscus sabdariffa extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Hibiscus sabdariffa extract is a natural product derived from the calyces of the Hibiscus sabdariffa plant. It is widely consumed as a beverage (commonly known as "hibiscus tea") and used in traditional medicine for its potential health benefits. The extract contains various bioactive compounds such as anthocyanins (including delphinidin 3-sambubioside and cyanidin 3-sambubioside), chlorogenic acid, myricetin 3-arabinogalactoside, quercetin 3-rutinoside and others[5]. Its primary investigated mechanisms include antihypertensive effects (possibly through vasodilation or diuretic action), mild laxative activity due to fruit acids in the plant[1][3], metabolic/lipid-lowering effects[4], anti-inflammatory properties[4], and possible antibiotic-like actions[1]. While it has been studied for lowering blood pressure and cholesterol levels—especially in people with hypertension—clinical evidence remains limited for most indications. Hibiscus sabdariffa extract is not developed by a single pharmaceutical company but is produced by various manufacturers worldwide primarily as a dietary supplement or food ingredient.

Other names
hibiscusjamaica sorrelkarkadekarkadired sorrelred tearosa de jamaicarosellarosellesoborodosour teazobo drink
02

Targets

CYP1A2 (Cytochrome P450 1A2)CYP2D6 (Cytochrome P450 2D6)ELANE (Human Neutrophil Elastase)CYP3A4 (Cytochrome P450 3A4)

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