hibiscus sabdariffa extract + olea europaea leaf extract

A combination product consisting of an extract from the **leaves of Olea europaea** (olive) and the **calyces of Hibiscus sabdariffa** (roselle), commonly formulated in a 13:2 weight ratio, has been studied as a nutraceutical for cardiovascular and gastrointestinal health. The mix functions primarily as an **L-type calcium channel blocker**, leading to **myorelaxant effects in the ileum and colon**, modulation of gut motility, and mild antihypertensive properties. The combination also **selectively inhibits inducible nitric oxide synthase (iNOS)**, which is relevant for inflammatory-driven gastrointestinal disorders and offers **pro-apoptotic activity towards human colorectal adenocarcinoma cells**. The main phenolic compounds are secoiridoids (primarily oleuropein and isomers) from olive leaf, and hibiscus acid from Hibiscus. The combination exerts synergistic effects, with higher cytotoxicity against cancer cells compared to the individual extracts. The formulation is positioned as a **nutraceutical** rather than a registered pharmaceutical, targeting mild hypertension, gastrointestinal motility disorders, and inflammatory bowel-related conditions[1].

Other names

hibiscus sabdariffa L. extract + olea europaea L. extractHibiscus sabdariffa extract + olive leaf extract