Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
HiCM-188
- Development stage
- Phase 3
- Lead developer
- Help Therapeutics
- Modality
- iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
- Administration
- Intramyocardial, Transcatheter Endocardial
01
Overview
**HiCM-188** is an investigational, off-the-shelf allogeneic human induced pluripotent stem cell-derived cardiomyocyte therapy developed by HELP Therapeutics for advanced heart failure, including severe chronic ischemic heart failure. The product consists of highly purified cardiomyocytes differentiated from human iPSCs under serum-free, vector-free, and integration-free manufacturing conditions. It is administered by direct intramyocardial injection, including transepicardial injection during coronary artery bypass graft surgery or catheter-based endocardial injection, with the therapeutic goal of replacing lost contractile myocardial cells and supporting cardiac remuscularization. HiCM-188 has entered clinical development in China, the United States, Singapore, and Thailand; a pivotal Phase III study in advanced heart failure is enrolling in China.
- Other names
- allogeneic human induced pluripotent stem cell-derived cardiomyocyteshuman iPSC-derived cardiomyocyte injection
Beyond the preview
Go deeper on HiCM-188.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on HiCM-188.