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High MAC-The First Affiliated Hospital of Anhui Medical University
- Development stage
- Unknown
- Lead developer
- The First Affiliated Hospital, Anhui Medical University
- Modality
- Small Molecules
- Administration
- Inhalation
01
Overview
High MAC-The First Affiliated Hospital of Anhui Medical University refers to a specific high-concentration dosing regimen of the volatile anesthetic sevoflurane used in clinical research. Specifically, it is a treatment arm in a randomized clinical trial (NCT04292561) conducted by The First Affiliated Hospital of Anhui Medical University to investigate the effects of deep versus light anesthesia on postoperative delirium (POD) and intraoperative electroencephalogram (EEG) patterns in elderly patients undergoing abdominal surgery. Sevoflurane, the active agent, is a small molecule inhalational anesthetic that functions primarily as a positive allosteric modulator of GABA-A receptors and an antagonist of NMDA receptors, leading to central nervous system depression and general anesthesia. The High MAC designation indicates a target minimum alveolar concentration (MAC) typically ranging from 1.0 to 2.0, intended to maintain a deeper state of anesthesia compared to Low MAC protocols.
- Brand names
- UltaneSojournSevorane
- Other names
- High MACHigh MAC sevofluraneHigh minimum alveolar concentration sevoflurane
02
Targets
NMDAR (Glutamate receptor ionotropic, NMDA)GABRR (GABA-A receptor subunit rho)Glycine receptor
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