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Drug intelligence / Profile preview
high molecular weight sodium hyaluronate
- Development stage
- Unknown
- Lead developer
- Anika Therapeutics
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intraarticular
01
Overview
**High molecular weight sodium hyaluronate** is the sodium salt form of hyaluronic acid, a long-chain glycosaminoglycan naturally present in human connective tissues. High molecular weight formulations, such as the one found in ORTHOVISC, possess a viscoelastic property permitting their use as intra-articular injections for supplementation of synovial fluid, leading to improved joint lubrication and shock absorption. The mechanism involves providing mechanical support and possibly modulating the inflammatory response in the joint. ORTHOVISC contains sodium hyaluronate extracted from rooster combs, with a molecular weight ranging from 1 to 2.9 million daltons, delivered as a 15 mg/mL solution for injection[1]. Its primary indication is pain management in osteoarthritis of the knee in patients unresponsive to conservative therapies[1][2][5].
- Brand names
- ORTHOVISC
- Other names
- high molecular weight sodium hyaluronansodium hyaluronate (high molecular weight)
02
Targets
CD44 (CD44 antigen)ICAM1 (Intercellular Adhesion Molecule 1)RHAMM (Hyaluronan-mediated motility receptor)
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