Drug intelligence / Profile preview

high-phenolic extra virgin olive oil

Development stage
Preclinical
Modality
Small Molecules, Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

High-phenolic extra virgin olive oil is a natural food product derived from olives (Olea europaea) that is characterized by a polyphenol content of at least 250 mg/kg. It is consumed as a dietary oil, not a pharmaceutical drug. Its primary bioactive constituents are a diverse group of phenolic compounds, including oleuropein, hydroxytyrosol, oleocanthal, tyrosol, ligstroside, and oleacein. Mechanistically, high-phenolic extra virgin olive oil exerts antioxidant effects (scavenging free radicals, inhibiting lipid oxidation), anti-inflammatory actions (inhibiting NF-κB activation and reducing production of inflammatory mediators), and influences cardiovascular risk factors (lowering LDL cholesterol, improving HDL cholesterol, lowering blood pressure, and improving endothelial function). Numerous observational, interventional, and mechanistic studies support its role in reducing the risk of cardiovascular disease, improving markers of inflammation and oxidative stress, and providing cognitive and neuroprotective benefits. It is not a pharmaceutical drug, but a functional food whose mechanism of action is mediated largely by its polyphenol content and their interaction with multiple cellular and metabolic pathways[1][3][4][5][6][7].

Other names
high-polyphenol extra virgin olive oilhigh phenolic EVOOpolyphenol-rich extra virgin olive oil
02

Targets

ICAM2 (ICAM-2)PPARG (Peroxisome proliferator-activated receptor gamma)

Beyond the preview

Go deeper on high-phenolic extra virgin olive oil.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on high-phenolic extra virgin olive oil.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call