Drug intelligence / Profile preview

highly purified urinary follicle stimulating hormone + cetrorelix

Development stage
Unknown
Lead developer
Merck KGaA
Modality
Recombinant Proteins and Enzymes, Peptides
Administration
Subcutaneous
01

Overview

This combination regimen is used in controlled ovarian hyperstimulation (COH) protocols for in vitro fertilization (IVF), specifically studied by the Riyadh Fertility and Reproductive Health center for women with poor ovarian response. The regimen consists of highly purified urinary follicle stimulating hormone (HPuFSH), which provides exogenous FSH to stimulate the development of multiple ovarian follicles, and a gonadotropin-releasing hormone (GnRH) antagonist, cetrorelix. Cetrorelix acts by competitively blocking GnRH receptors in the pituitary gland, thereby preventing premature luteinizing hormone (LH) surges that could lead to untimely ovulation. This specific protocol is often evaluated as a standard of care against which adjunctive therapies, such as growth hormone (somatropin), are tested to improve clinical outcomes in patients identified as "poor responders."

Brand names
FostimonCetrotide
Other names
HPuFSH + GnRH antagonistHPuFSH/GnRH antagonisthighly purified urinary FSH + GnRH antagonist
02

Targets

FSHR (Follicle-stimulating hormone receptor)GnRHR (Gonadotropin-releasing hormone receptor)

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