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Hino-Sankyu-To is a traditional Japanese Kampo (herbal) medicine manufactured by Hino Pharmaceutical. It is a multi-ingredient botanical formulation primarily investigated for the treatment of periodontal disease. The medicine is composed of various herbal extracts that are believed to possess anti-inflammatory and antimicrobial properties. In clinical trials, such as jRCT1031250072, it has been compared to conventional antibiotics like azithromycin for its efficacy in reducing periodontal pocket depth and the counts of periodontal pathogens like *Porphyromonas gingivalis*. The drug is typically administered orally, and specific protocols have explored holding the solution in the mouth (buccal application) for a short duration before swallowing to enhance local therapeutic contact with the gingival tissues.
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