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Drug intelligence / Profile preview
hispidol B
- Development stage
- Preclinical
- Lead developer
- Noguchi Memorial Institute for Medical Research
- Modality
- Small Molecules
01
Overview
Hispidol B is a naturally occurring tirucallane triterpene (limonoid) isolated from various plant species, including *Turraea pubescens*, *Cedrela sinensis*, and *Phellodendron amurense*. In preclinical research, hispidol B has been identified via pharmacophore modeling and molecular docking as a potential activator of the abnormal Dauer Formation Protein 12 (DAF-12) receptor. This receptor plays a critical role in regulating the transition between developmental arrest (dauer stage) and reproductive growth in nematodes. By activating DAF-12, hispidol B is being investigated as a potential therapeutic candidate to deactivate the autoinfection life cycle stage of *Strongyloides stercoralis*, the causative agent of strongyloidiasis.
- Other names
- (3S,23R,24S)-Tirucall-7-ene-3,23,24,25-tetrolLanost-7-ene-3,23,24,25-tetrol, (3beta,13alpha,14beta,17alpha,20S,23R,24S)-
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