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histaglobulin
- Development stage
- Phase 4
- Lead developer
- Bharat Serums and Vaccines
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Subcutaneous, Intramuscular
01
Overview
Histaglobulin is a sterile injectable preparation composed of human normal immunoglobulin (gamma globulin) coupled with a small amount of histamine dihydrochloride and sodium thiosulphate. It is used primarily for the prevention and treatment of various allergic conditions such as allergic rhinitis, eczema, urticaria (including chronic urticaria), generalized skin allergies, asthma, atopic dermatitis, and sometimes migraine. The drug works by inducing the production of antihistaminic antibodies that neutralize free histamine released during allergic reactions. This leads to a reduction in allergy symptoms over time. The mechanism involves stimulating an immune response against the histamine-immunoglobulin complex; repeated dosing increases antibody titers and can provide long-term remission from symptoms[1][2][3][4][5]. It is not recommended for use during acute allergic attacks or in certain populations such as pregnant women.
- Brand names
- HISTOGLOBHistobulin
- Other names
- histaglobinHistamine-fixed immunoglobulinHuman Normal Immunoglobulin + Histamine Dihydrochloride + Sodium Thiosulphate
02
Targets
HRH1 (Histamine H1 Receptor)HRH2 (Histamine H2 Receptor)HRH3 (Histamine Receptor H3)HRH4 (Histamine H4 receptor)
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