Histapyrrodine

Histapyrrodine is a first-generation ethylenediamine H1-antihistamine with anticholinergic (antimuscarinic) and moderate sedative properties. It acts primarily by antagonizing the histamine H1 receptor, thereby reducing the effects of endogenous histamine in allergic conditions such as allergic rhinitis, conjunctivitis, and urticaria. By blocking H1 receptors and interfering with downstream signaling pathways (including phospholipase C and phosphatidylinositol), it decreases inflammatory responses mediated by NF-κB transcription factor activity. This leads to reduced antigen presentation and pro-inflammatory cytokine expression as well as increased mast cell stability. As a first-generation antihistamine, it readily crosses the blood-brain barrier and can cause central nervous system effects such as sedation. Histapyrrodine was also investigated for its neuro-sedative properties in treating anxiety and states of aggression[2][3][4][5][6].

Other names

HistapirrodinaHistapyrrodinum493-80-1UNII-0FYM61NG4DUNII0FYM61NG4DUNII 0FYM61NG4D