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HIV-1 gag DNA + IL-12 DNA
- Development stage
- Unknown
- Lead developer
- Aurobindo Pharma
- Modality
- DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
HIV-1 gag DNA + IL-12 DNA is an investigational HIV vaccine consisting of a DNA plasmid expressing the HIV-1 gag gene administered together with plasmid IL-12 DNA as a cytokine adjuvant. The vaccine is designed to induce cellular immune responses against HIV-1. The gag component typically contains an RNA-optimized truncated HIV-1 gag gene (p37) derived from strain HXB2 or other HIV-1 gag variants. IL-12 plasmid DNA is included as a molecular adjuvant to potentially enhance immune responses. The vaccine is typically administered via intramuscular injection, sometimes with electroporation to improve cellular uptake and immunogenicity.
- Other names
- HIV-MAG + IL-12 pDNAp37 DNA + IL-12 DNAp24CE DNA + IL-12 DNA
02
Targets
IL-12R (Interleukin-12 receptor)HIV-1 Gag-specific T cell receptor (HIV-1 Gag TCR)
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