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HIV-1 virus-like particle vaccine

Development stage
Preclinical
Lead developer
AdaptVac
Modality
Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The HIV-1 virus-like particle vaccine is a preclinical-stage vaccine candidate being developed by AdaptVac, a Danish biotechnology company. Utilizing their proprietary modular capsid virus-like particle (cVLP) platform, the vaccine is engineered to display HIV-1 envelope glycoprotein antigens on the surface of cVLP scaffolds. This architecture is designed to mimic the repetitive structure of a virus, thereby eliciting a robust and targeted immune response against HIV-1. The primary objective of the candidate is the prevention or control of HIV-1 infection and the progression to AIDS.

Other names
HIV-1 cVLP vaccineHIV1 cVLP vaccineHIV 1 cVLP vaccine
02

Targets

CD4+ T-cell receptor recognizing HIV-1 Envelope-derived peptides presented by MHC class IIBCR-HIV-Env (HIV-1 envelope-specific B-cell receptor)Human immunodeficiency virus type 1 envelope glycoprotein 140 trimerCD8+ T-cell receptor recognizing HIV-1 envelope glycoprotein-derived peptides

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