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HJ787 is a novel, topical small molecule androgen receptor (AR) antagonist developed by Chengdu Huajian Future Technology for the treatment of acne vulgaris. The drug is designed to specifically target and inhibit the androgen receptor within the skin's sebaceous glands, thereby reducing sebum production, which is a key driver in the pathogenesis of acne. By utilizing a topical formulation, HJ787 aims to provide localized therapeutic effects while minimizing systemic exposure and the potential for systemic anti-androgenic side effects. It is currently being evaluated in clinical trials to determine its safety, tolerability, and preliminary efficacy in patients with moderate-to-severe acne.
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