Drug intelligence / Profile preview

HK262

Development stage
Unknown
Lead developer
Institute of Organic Chemistry and Biochemistry of the CAS
01

Overview

HK262: sourced facts only. name: "Here, we report the identification of 6d as a METTL21A inhibitor and the subsequent structure-activity relationship (SAR) study of analogues decorated with various fluorinated substituents, leading to metabolically stable 6n (HK262) with an IC50 1.10 μM." [PMID:42623743]; target: "Here, we report the identification of 6d as a METTL21A inhibitor and the subsequent structure-activity relationship (SAR) study of analogues decorated with various fluorinated substituents, leading to metabolically stable 6n (HK262) with an IC50 1.10 μM." [PMID:42623743]; developer: "Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Chemical Technology, University of Chemistry and Technology, Prague, Czech Republic." [PMID:42623743]

02

Targets

METTL21A (Protein N-lysine methyltransferase METTL21A)

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