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HKG-319
- Development stage
- Phase 1
- Lead developer
- Sinopharm Ruifulai Pharmaceutical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
HKG-319 is an oral soluble film formulation of the atypical antipsychotic brexpiprazole, developed by Sinopharm Ruifulai Pharmaceutical. As a serotonin-dopamine activity modulator (SDAM), brexpiprazole acts as a partial agonist at dopamine D2 and serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptors. This film formulation is designed to provide an alternative delivery method for patients with schizophrenia, potentially improving adherence and ease of administration compared to traditional oral tablets. HKG-319 is currently undergoing clinical evaluation in bioequivalence studies to compare its pharmacokinetic profile with the reference product, Rxulti (brexpiprazole tablets).
- Other names
- brexpiprazole oral soluble film
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)ADRA1B (α1B)ADRA2C (α2C)DRD2 (Dopamine D2 Receptor)
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