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HM12460A
- Development stage
- Phase 1
- Lead developer
- Hanmi Pharmaceutical
- Modality
- Peptides, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Subcutaneous
01
Overview
HM12460A (also known as LAPS-Insulin) is a long-acting basal insulin analog developed by Hanmi Pharmaceutical using its proprietary LAPSCOVERY (Long-Acting Protein/Peptide Discovery) platform. This technology extends the half-life of the insulin molecule by conjugating it to a human immunoglobulin Fc fragment via a non-peptidyl linker, allowing for once-weekly subcutaneous administration. It is intended for the treatment of type 1 and type 2 diabetes mellitus by providing sustained glucose-lowering effects and potentially reducing the risk of hypoglycemia compared to daily basal insulins. Development was previously partnered with Sanofi, but rights were returned to Hanmi in late 2016.
- Other names
- LAPS-InsulinLAPSInsulin
02
Targets
INSR (Insulin receptor)
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