HMGB2 shRNA

HMGB2 shRNA is an experimental gene-silencing tool designed to inhibit the expression of High Mobility Group Box 2 (HMGB2), a protein that is typically absent in the normal adult brain but highly expressed in high-grade gliomas. HMGB2 is involved in DNA double-strand break repair and the p53-p21-RB signaling pathway, contributing to radiation and temozolomide resistance. By utilizing short hairpin RNA (shRNA) delivered via lentiviral vectors, this therapeutic approach targets HMGB2 mRNA for degradation, leading to a significant reduction in protein levels. Preclinical studies in glioblastoma (GBM) cell lines have demonstrated that HMGB2 knockdown reduces cell proliferation and colony formation, and effectively sensitizes tumor cells to radiation therapy, regardless of their TP53 mutation status.

Other names

HMGB2 knockdownHMGB-2 knockdownHMGB 2 knockdownHMGB2-KDHMGB-2-KDHMGB 2-KD