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hMPV_Y low dose vaccine
- Development stage
- Unknown
- Lead developer
- GSK
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
hMPV_Y low dose vaccine is an investigational human metapneumovirus (hMPV) vaccine candidate developed by GSK. It was evaluated as part of a Phase 1/2 clinical trial (NCT04141540) designed to assess the safety, reactogenicity, and immunogenicity of various hMPV and RSV/hMPV combination vaccine formulations in younger adults (18-49 years) and older adults (60-80 years). The 'Y' designation refers to a specific investigational formulation of the hMPV vaccine, administered at a low dose via intramuscular injection. The vaccine aims to elicit a protective immune response against hMPV, a significant cause of viral respiratory tract infections, particularly in infants, the elderly, and immunocompromised individuals.
02
Targets
HMPV F (Human metapneumovirus fusion protein)TCR (T-cell receptor (TCR) recognizing human metapneumovirus (hMPV) fusion (F) protein-derived peptides presented by major histocompatibility complex (MHC))
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