hMSC-WT

hMSC-WT (Wild-Type Human Mesenchymal Stem Cells) refers to unmodified multipotent stromal cells used in regenerative medicine and as a therapeutic benchmark in neurodegenerative disease research. These cells are typically isolated from bone marrow, adipose tissue, or umbilical cord blood and are characterized by their ability to differentiate into multiple lineages and their potent secretome, which includes various growth factors and anti-inflammatory cytokines. In the context of Amyotrophic Lateral Sclerosis (ALS), hMSC-WT cells are investigated for their capacity to modulate the immune response, reduce macrophage-mediated inflammation (specifically by lowering levels of TNF-α and IL-1β), and provide a supportive microenvironment for motor neurons and glial cells. While often used as a control for genetically enhanced MSCs, such as those modified to overexpress glial cell line-derived neurotrophic factor (hMSC-GDNF), unmodified hMSCs themselves possess intrinsic therapeutic potential through paracrine signaling and direct cellular interactions.

Other names

Wild-type human mesenchymal stem cellsUnmodified human mesenchymal stem cellshMSC