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hNeo-T
- Development stage
- Phase 1
- Lead developer
- BGI Genomics
- Modality
- Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Intravenous (injection)
01
Overview
hNeo-T is a targeted neoantigen haploidentical T cell therapy developed for the treatment of neoplasms, specifically relapsed or refractory Epstein-Barr virus (EBV)-positive T-cell lymphoma. This investigational therapy involves the use of haploidentical (partially HLA-matched) donor-derived T cells that are engineered or selected to target patient-specific tumor neoantigens, aiming to enhance anti-tumor immune responses. The approach leverages advances in immunotherapy and personalized medicine by focusing on unique antigens present on cancer cells but not normal tissues. The drug is currently being evaluated in early phase 1 clinical trials for safety, tolerability, and initial efficacy[1][2][3].
- Other names
- Targeted Neoantigen Haploidentical T Cell Injection
02
Targets
pMHC (Peptide-MHC complex family)
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