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Ho-166 QuiremSpheres (holmium (166Ho) microspheres)
- Development stage
- Unknown
- Lead developer
- Terumo
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intra-arterial
01
Overview
Ho-166 QuiremSpheres is a radiopharmaceutical device consisting of poly-L-lactic acid (PLLA) microspheres loaded with the radioactive isotope Holmium-166 (166Ho). It is used for Selective Internal Radiation Therapy (SIRT), also known as radioembolization, to treat primary and metastatic liver tumors. Holmium-166 is a high-energy beta-emitter with a half-life of approximately 26.8 hours, which also emits gamma radiation, allowing for SPECT imaging and MRI-based dosimetry. The microspheres are administered via the hepatic artery, where they lodge in the tumor's microvasculature, delivering localized radiation while sparing healthy liver tissue.
- Brand names
- QuiremSpheres
- Other names
- Holmium-166 microspheresHolmium166 microspheresHolmium 166 microspheres166Ho microspheres
02
Targets
DNA
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