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Homogeneous cross-linked chitosan is a viscosupplement in clinical development by Haohai Healthcare Holdings for the treatment of osteoarthritis and other joint disorders. Administered via intra-articular injection, the product consists of a cross-linked chitosan polymer designed to provide mechanical lubrication and cushioning within the synovial space. By mimicking the rheological properties of healthy synovial fluid, it aims to reduce mechanical friction between articular surfaces, protect cartilage, and alleviate pain associated with joint degeneration. Unlike traditional linear polysaccharides, the cross-linked structure of this chitosan formulation is intended to enhance its residence time and mechanical stability within the joint.
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