homoharringtonine

Homoharringtonine is a cytotoxic alkaloid originally isolated from plants of the genus Cephalotaxus. It acts as a protein synthesis inhibitor by binding to the 80S ribosome in eukaryotic cells and interfering with translation elongation. This results in inhibition of leukemic cell proliferation by blocking progression through the cell cycle and inducing apoptosis. Homoharringtonine is primarily used for hematologic malignancies such as chronic myelogenous leukemia (CML), especially in patients resistant or intolerant to two or more tyrosine kinase inhibitors. It has also shown efficacy against other acute leukemias and is being explored for additional cancer indications[1][2][5][7][8].

Brand names

SynriboMyelostatCeflatonin

Other names

Omacetaxine mepesuccinate高三尖杉酯碱Cephalotaxine 4-methyl (2R)-2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate