homosildenafil

Homosildenafil is a **synthetic small-molecule phosphodiesterase type 5 inhibitor** and a structural analog of sildenafil and vardenafil. It has been reported to retain PDE5 inhibitory activity at lower potency than sildenafil, but it is **not an approved medicine and is not a legitimate therapeutic development candidate**. Instead, homosildenafil is best known as an **illicit adulterant** found in counterfeit or undeclared sexual enhancement products and dietary supplements, and it is mainly encountered as an **analytical reference standard** for forensic, quality-control, and regulatory testing rather than as a drug in clinical development. Because it may be consumed unknowingly in adulterated products, it presents meaningful safety and public health concerns similar to other undeclared PDE5 inhibitor analogs.

Other names

methyl-sildenafil