honey bee venom-loaded calcium oxide nanocomposites

Honey bee venom-loaded calcium oxide nanocomposites are an experimental therapeutic formulation in which bioactive components of honey bee venom are incorporated onto calcium oxide (CaO) nanoparticles. The purpose of this nanocomposite is to utilize the anti-tumor, antibacterial, and anti-inflammatory effects of bee venom—primarily attributed to constituents such as melittin and phospholipase A2—while leveraging the drug delivery and biologically active properties of CaO nanoparticles. The calcium oxide nanoparticles function as nanocarriers, improving the solubility and stability of bee venom while controlling its release and protecting it from degradation. Mechanistically, the composite is thought to induce cytotoxicity in cancer cells through the combined actions of bee venom (which disrupts cellular membranes and induces apoptosis via caspase activation, membrane lysis, and NF-κB inhibition) and CaO nanoparticles (which generate reactive oxygen species, cause oxidative stress, and disrupt cell membranes). The platform is being investigated for cancer therapy (notably breast cancer), bacterial infections, and wound healing, but is currently at an early preclinical/in vitro research stage[2][3][5][7].

Other names

honey bee venom-CaO nanocompositesbee venom-loaded CaO nanoparticlesBV-CaO nanocomposites