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Honghua Xiaoyao Tablet
- Development stage
- Unknown
- Lead developer
- Beijing University of Chinese Medicine East Hospital
- Administration
- Oral
01
Overview
Honghua Xiaoyao Tablet is a Traditional Chinese Medicine (TCM) formulation used primarily for the treatment of premenstrual syndrome (PMS) and menstrual irregularities associated with the TCM pattern of liver depression and qi stagnation. It is a modified version of the classic Xiaoyao San formula, enriched with *Carthamus tinctorius* (Honghua/Safflower) to enhance its blood-activating and stasis-resolving properties. The formula typically includes *Bupleurum chinense*, *Angelica sinensis*, *Paeonia lactiflora*, *Atractylodes macrocephala*, *Poria cocos*, and *Glycyrrhiza uralensis*. It works by regulating the neuroendocrine system, particularly the hypothalamic-pituitary-ovarian axis, and exerting anti-inflammatory and analgesic effects. A Phase 4 clinical trial (ChiCTR2300071827) conducted by the Oriental Hospital of Beijing University of Chinese Medicine evaluated its efficacy and safety compared to the standard Xiaoyao Pill in women with PMS.
- Brand names
- Honghua Xiaoyao TabletHonghua Xiaoyao Pian
- Other names
- Honghua Xiaoyao
02
Targets
CYP11A1 (Cholesterol side chain cleavage enzyme)CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)CYP19A1 (Aromatase)ESR1 (ERα)GSK3 (Glycogen synthase kinase 3 beta)HSD3B2 (3-beta-hydroxysteroid dehydrogenase type 2)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)GR (Glucocorticoid receptor)
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